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Unlocking the Secrets of Bacterial Persisters: A Key to Better Antibiotic Therapy

Persisters are a type of bacterial cell that can survive exposure to antibiotics and other stressors. These cells are able to enter a dormant or quiescent state, which makes them less susceptible to killing by antibiotics and other therapies. Persisters can remain dormant for extended periods of time, sometimes for years, until conditions become favorable for them to grow and multiply again.

Persisters are thought to be an important factor in the recalcitrance of bacterial infections, such as tuberculosis and other mycobacterial infections, as well as in the development of antibiotic resistance. They can also contribute to the persistence of bacterial infections in the body, even after treatment with antibiotics.

Research on persisters is ongoing, and scientists are working to develop new strategies for targeting these cells in order to improve the effectiveness of antibiotic therapy and prevent the development of antibiotic resistance.

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